Medway Community Healthcare Medway NHS Trust Foundation Trust
Medway Clinical Commissioning Group Swale Clinical Commissioning Group

High Cost Drugs

Click here to download the Kent and Medway Health Economy National Tariff Excluded Drugs Manual
Also known as the High Cost Drugs (HCD) Manual. Last updated: August 2023

The purpose of this manual is to describe the process for funding high cost drugs or devices excluded from the National Tariff payment system, (previously known as National Tariff Exclusions). These drugs or devices are only commissioned for those indications listed under the individual drug. With regard to items commissioned by ICB, drugs or devices may not be commissioned across every ICB.

Drugs or devices may not be commissioned across every ICB. Information on whether a ICB has commissioned a drug can be found in the “Commissioner” column in the manual. Blueteq forms must be completed in all cases. Invoices will be refused for indications not listed within this manual.

If a drug is being requested to treat a patient for an indication/condition NOT listed in the manual then an Individual Funding Request (IFR) or Business Case must be made to either the ICB or NHS England depending on who currently commissions the drug for other uses. IFR requests may be made for rare diseases or exceptional circumstances. A business case would be required where it is expected or foreseeable that there is a cohort of patients affected. Please contact the named individual at the front of the manual (link above) for preliminary advice on whether an IFR or business case is required.

The tables below contain a summary of the high cost drugs, for full details please see the entries within the manual.

Drug Name Indication Commissioner
Abacavir (Ziagen®) HIV in combination with other anti-retroviral drugs NHS England
Abaloparatide Male juvenile osteoporosis NHS England
Abatacept (Orencia®) Rheumatoid arthritis (1st line biologic ) ICB
Abatacept (Orencia®) Rheumatoid Arthritis (2nd line biologic) ICB
Abatacept (Orencia®) Juvenile Idiopathic arthritis (adult only)  ICB
Abatacept (Orencia®) Severe treatment resistant morphoea NHS England
Abatacept (Orencia®) Refractory idiopathic inflammatoy myopathies NHS England
Abatacept (Orencia®) Juvenile idiopathic arthritis (paediatric) NHS England
Abrocitinib (Cibinqo®) Moderate to severe atopic dermatitis ICB
Abrocitinib (Cibinqo®) Moderate to Severe atopic Dermatitis - paediatrics NHS England
Acalabrutinib (Calquence ®) Cancer NHS England
Acoramidis Amyloidosis NHS England
Adalimumab (Humira®, Imraldi®, Amgevita®, Yuflyma®) Ankylosing Spondylitis and Axial Spondyloarthritis  ICB
Adalimumab (Humira®, Imraldi®, Amgevita®, Yuflyma®) Chrohn’s Disease(1st and 2nd line biologic) ICB
Adalimumab (Humira®, Imraldi®, Amgevita®, Yuflyma®) Psoriasis ICB
Adalimumab (Humira®, Imraldi®, Amgevita®, Yuflyma®) Psoriatic Arthritis ICB
Adalimumab (Humira®, Imraldi®, Amgevita®, Yuflyma®) Rheumatoid arthritis (1st line biologic ) ICB
Adalimumab (Humira®, Imraldi®, Amgevita®, Yuflyma®) Rheumatoid Arthritis (2nd line biologic) ICB
Adalimumab (Humira®, Imraldi®, Amgevita®, Yuflyma®) Juvenile idiopathic arthritis (adult) ICB
Adalimumab (Humira®, Imraldi®, Amgevita®, Yuflyma®) Ulcerative Colitis (moderate to severe) ICB
Adalimumab (Humira®, Imraldi®, Amgevita® Yuflyma ®) Juvenile idiopathic arthritis (paediatric) NHS England
Adalimumab (Humira®, Imraldi®, Amgevita® Yuflyma ®) Uveitis - Adult NHS England
Adalimumab (Humira®, Imraldi®, Amgevita® Yuflyma ®) Hidradenitis Suppurativa NHS England
Adalimumab (Humira®, Imraldi®, Amgevita® Yuflyma ®) Plaque psoriasis in children NHS England
Adalimumab (Humira®, Imraldi®, Amgevita® Yuflyma ®) Behcet's Syndrome NHS England
Adalimumab (Humira®, Imraldi®, Amgevita® Yuflyma ®) Non bacterial osteomyelitis/osteitis NHS England
Aducanumab Alzheimers disease - young onset dementia NHS England
Afaitresgene autoleucel Cancer Sarcoma NHS England
Afatinib (Gilotrif®) Cancer NHS England
Afamelanotide Eryhtopoietic Protoporphyria NHS England
Aflibercept (Eylea®) Macular degeneration(wet age-related) ICB
Aflibercept (Eylea®) Diabetic macular oedema ICB
Aflibercept (Eylea®) Choroidal Neovascularisation ICB
Aflibercept (Eylea®) Macular Oedema after BRVO(Branch Retinal Vein Occlusion) ICB
Aflibercept (Eylea®) Macular Oedema secondary to central retinal vein occlusion ICB
Aflibercept (Zaltrap®) Cancer NHS England
Agalsidase Alfa (Replagal®) Fabry’s Disease NHS England
Agalsidase Beta (Fabrazyme®) Fabry’s Disease NHS England
Albutrepenonacog alfa (Factor IX - recombinant) Idelvion®  Haemophilia B NHS England
Aldesleukin (Proleukin®) Cancer NHS England
Alemtuzumab (MabCampath®) Multiple Sclerosis NHS England
Alemtuzumab (MabCampath®) Pre-transplant immunosuppression; Islet transplantation NHS England
Alemtuzumab (MabCampath®) Behcet's Syndrome NHS England
Alglucosidase Alfa (Myozyme®) Pompe disease NHS England
Alirocumab (Praluent®) Primary hypercholesterolaemia or mixed dyslipidaemia ICB
Alirocumab (Praluent®) Primary heterozygous-familial hypercholesterolaemia ICB
Alitretinoin (Toctino®) Eczema (chronic) ICB
Alpelisib Cancer NHS England
Alpha Mannosidase Recombinant Human Alpha Mannosidase Deficiency NHS England
Ambrisentan (Volbris®) Pulmonary arterial hypertension NHS England
Amifampridine phosphate (Firdapse®) Lambert-Easton Myasthenic Syndrome NHS England
Amikacin inhalation Fungal infection NHS England
Amikacin liposomal (Arikayce®) Cystic Fibrosis NHS England
Amivantamab (Rybrevant®) Cancer TBC
Amphotericin liposomal (Abelcet®, AmBisome®) Fungal infection NHS England
Anabasum Scleroderma NHS England
Anakinra (Kineret®) Castleman's disease NHS England
Anakinra (Kineret®) Haemophagocytic lymphohistiocytosis (HLH) NHS England
Anakinra (Kineret®) Adult Onset Still's disease NHS England
Anakinra (kineret®) Juvenile Arthritis (paediatric) NHS England
Anakinra (kineret®) Periodic fevers and autoinflammatory conditions NHS England
Anakinra (kineret®) Cryopyrin Associated Periodic Syndrome (CAPS) NHS England
Andexanet alfa (Andexxa®) Anticoagulation reversal from apixaban or rivaroxaban ICB
Anidulafungin (Ecalta®) Fungal infection NHS England
Anifrolumab SLE NHS England
Antilymphocyte globulin Aplastic Anaemia Organ Transplant NHS England
Antithrombin III As per BCSH Guidelines for specialised indications NHS England
Antithymocyte immunoglobulin Aplastic Anaemia Organ Transplant NHS England
Apalutamide (Erleada®) Cancer NHS England
Apremilast (Otezla®) Psoriatic Arthritis ICB
Apremilast (Otezla®) Moderate to severe plaque psoriasis ICB
Arimoclomol Niemann-pick disease NHS England
Asciminib Cancer NHS England
Asfotase alpha (Strensiq®) Hypophosphatasia NHS England
Atacicept Systemic lupus erythematosus (SLE) NHS England
Ataluren (Translarna®) Duchenne Muscular Dystrophy NHS England
Atazanavir (Reyataz®) HIV in combination with other anti-retroviral drugs NHS England
Atidarsagene Autotemcel (Libmeldy®) Metachromatic leukodystophy (MLD) NHS England
Autologous lentiviral was stem cell therapy Primary immunodeficincy - wiskott aldrich syndrom NHS England
Autologous serum eye drops Dry eye NHS England
Avacopan Granulomatosis NHS England
Avalglucosidase alfa Glycogen storage disease type II (pompe disease) NHS England
Avalotcagene ontaprvovec Ornithine carbamoyl transferase deficiency NHS England
Avapritinib (Ayvakyt®) Cancer NHS England
Avatrombopag (Doptelet®) Primary chronic immune thrombocytopenia ICB
Avatrombopag (Doptelet®) Thrombocytopenia in people with chronic liver disease ICB
Axitinib (Inlyta®) Cancer NHS England
Azacitidine  (Vidaza®) Cancer NHS England
Aztreonam lysine (Cayston®) Cystic Fibrosis NHS England
Aztreonam lysine (Cayston®) Cystic Fibrosis- continuous NHS England
Bardoxolone methyl CKD caused by alport syndrome NHS England
Baricitinib (Olumiant®) Moderate to severe atopic dermatitis ICB
Baricitinib (Olumiant®) Rheumatoid Arthritis ICB
Baricitinib (Olumiant®) Monogenic interferonopathies NHS England
Basiliximab (Simulect®) Renal Transplant NHS England
Beclabuvir Hepatitis C NHS England
Bedaquiline Fumarate (Sirturo®) Extensively Drug Resistant TB NHS England
Bedaquiline Fumarate (Sirturo®) Multi drug resistant TB NHS England
Begelomab (Begedina®) Graft versus host disease NHS England
Belatacept (Nulojix®) Renal Transplant
NHS England
Belimumab (Benlysta®) Systemic lupus erythematosus (SLE) NHS England
Benralizumab (Fasenra®) Asthma NHS England
Berotralstat (Orladeyo®) Hereditary angioedema - prophylactic treatment NHS England
Betaine (Cystadane®) Homocystinuria NHS England
Bevacizumab  (Avastin®) Choroidal neovascularisation (CNV) due to causes other than age-related macular degeneration (AMD) or pathological myopia (PM) ICB
Bevacizumab  (Avastin®) Neurofibromatosis NHS England
Bevacizumab  (Avastin®) Colorectal cancer NHS England
Bevacizumab  (Avastin®) Colorectal cancer NHS England
Bevacizumab  (Avastin®) Lung cancer NHS England
Bevacizumab  (Avastin®) Cancer NHS England
Bictecravir HIV in combination with other anti-retroviral drugs NHS England
Bimagrumab Inclusion Body Myositis NHS England
Bimekizumab (Bimzelx®) Psoriasis ICB
Biotin (Cerenday®) Multiple Sclerosis NHS England
Birch bark extract  Epidermolysis Bullosa NHS England
Bis-Choline tetrethiomolybdate Wilson's Disease NHS England
Bizalmogene ralaplasmid Cervical dysplasia NHS England
Bortezomib  (Velcade®) Organ rejection post kidney transplant NHS England
Bortezomib  (Velcade®) Cancer NHS England
Bosentan  (Tracleer®) Digital Ulcers NHS England
Bosentan  (Tracleer®) Pulmonary arterial hypertension NHS England
Bosutinib (Bosulif®) Cancer NHS England
Botaretigene Sparoparvovec Retinal disorders  NHS England
Brain cancer Vaccine (DCVax-L) Cancer TBC
Brimapitide (Sonsuvi®) Acute Sensorineural hearing loss NHS England
Brodalumab (Kyntheum®) Moderate to severe plaque psoriasis ICB
Brolucizumab (Beovu®) Diabetic macular oedema ICB
Brolucizumab (Beovu®) Macular degeneration(wet age-related) ICB
Buleviritide Compensated liver disease NHS England
Burosumab (Crysvita®) X linked Hypophosphataemia NHS England
C1 Esterase inhibitor (Berinert®, Cinryze®) Hereditary angioedema - acute treatment only NHS England
C1 Esterase inhibitor (Berinert®, Cinryze®) Hereditary angioedema – prophylactic treatment NHS England
C1 Esterase inhibitor (Berinert®, Cinryze®) Hereditary angioedema - prophylactic treatment in children (cinryze only) NHS England
Cabotegravir (vocabria®) HIV in combination with other anti-retroviral drugs NHS England
Calcifediol Inborn Errors in Primary Bile Acid Synthesis NHS England
Calcium, magnesium, potassium + sodium oxybate Narcolepsy - paediatrics NHS England
Canakinumab (Ilaris®) Cryopyrin Associated Periodic Syndrome (CAPS) NHS England
Canakinumab (Ilaris®) Periodic fever syndromes: TRAPS, HIDS/MKD and FMF NHS England
Canakinumab (Ilaris®) Juvenile Arthritis (paediatric) NHS England
Cannabidiol Tuberous sclerosis syndrome NHS England
Cannabidiol (as epidiolex) Dravet Syndrome NHS England
Cannabidiol (as epidiolex) Lennox gestaut syndrome NHS England
Canpuldencel - T Cancer - Glioblastoma NHS England
Caplacizumab (Cablivi®) Thrombotic Thrombocytopenic pupura NHS England
Carbidopa + levodopa + entacapone infusion Parkinson’s disease NHS England
Carglumic acid (Carbaglu®) Urea cycle disorders NHS England
Carnitine (Carnitor®) Carnitine deficiency NHS England
Caspofungin (Cancidas®) Fungal infection NHS England
Cemiplimab Cancer NHS England
Cenergermin (Oxervate®) Neurotrophic keratitis NHS England
Cerliponase alpha (Brineura®) Neuronal ceroid lipofuscinosis NHS England
Certolizumab pegol (Cimzia®) Rheumatoid Arthritis ICB
Certolizumab pegol (Cimzia®) Moderate to severe plaque psoriasis ICB
Certolizumab pegol (Cimzia®) Psoriatic Arthritis ICB
Certolizumab pegol (Cimzia®) Ankylosing Spondylitis and Axial Spondyloarthritis  ICB
Cetuximab (Erbitux®) Cancer NHS England
Chenodeoxycholic acid (Chenodeoxycholic acid sigma-tau®) Cerebrotendinous xanthomatosis (CTX) NHS England
Chenodeoxycholic acid (Chenodeoxycholic acid sigma-tau®) Primary biliary cirrhosis NHS England
Chlormethine Mycosis Fungoides - type cutaneous T-cell lymphoma NHS England
Cholic acid Inborn Errors in Primary Bile Acid Synthesis NHS England
Ciltacabtagene Autoleucel (Carvykit®) Cancer TBC
Cipaglucosidase alfa with miglustat Pompe disease NHS England
Ciprofloxacin inhalation Cystic Fibrosis NHS England
Ciprofloxacin inhalation liposomal Cystic Fibrosis NHS England
Cladribine (Leustat®, Litak®) Multiple sclerosis NHS England
Cladribine (Leustat®, Litak®) Pulmonary Langerhans Histiocytosis NHS England
Cobimetinib Cancer - melanoma  NHS England
Cobistat (Tybost®) HIV in combination with other anti-retroviral drugs NHS England
Co-careldopa intestinal gel (Duodopa®) Parkinson’s disease NHS England
Colistimethate sodium (Colomycin®, Promixin®, Colobreathe®) Cystic Fibrosis NHS England
Collagenase clostridium hystoliticum (Xiapex®) Dupuytren’s contracture in patients with a palpable cord ICB
Concizumab Prevention of bleeding episodes in haemophilia A or B NHS England
Conestat alfa (Ruconest®) Hereditary angioedema - acute treatment only NHS England
Copper Histidinate Menkes disease NHS England
Crizanlizumab (Adakveo®) Sickle Cell Disease NHS England
Crizotinib (Xalkori®) Cancer NHS England
Crovalimab Paroxysmal Nocturnal Haemoglobinuria NHS England
Cyclic pyranopterin monophosphate Molybdenum cofactor deficiency NHS England
Cysteamine (mercaptamine) Nephropathic Cystinosis NHS England
Dabrafenib (Tafinlar®) Cancer NHS England
Damoctocod alfa pegol (Factor VIII - recombinant) (Jivi®) Haemophilia A NHS England
Danicopan Paroxysmal Nocturnal Haemoglobinuria NHS England
Darbepoetin alpha Dialysis - induced anaemia NHS England
Darunavir (Prezista®) HIV in combination with other anti-retroviral drugs NHS England
Dasabvir (Exviera®) Hepatitis C NHS England
Dasatinib (Sprycel®) Cancer NHS England
Decitabine (Dacogen®) Cancer NHS England
Deferasirox (Exjade®) Iron chelation in thalassaemia and sickle cell NHS England
Deferiprone (Ferriprox®) Iron chelation in thalassaemia and sickle cell NHS England
Defibrotide (Defitelio®) Hepatic veno-occlusive disease NHS England
Delamanid (Deltyba®) Extensively drug resistant TB and multi drug resistant TB NHS England
Delandistrogene Moxaparvovec Duchenne Muscular Dystrophy NHS England
Desferrioxamine (Desferal®) Iron chelation in thalassaemia and sickle cell NHS England
Deucravacitinib (Sotyktu®) Psoriasis ICB
Dexamethasone intravitreal implant (Ozurdex®) Macular oedema (retinal vein occlusion) ICB
Dexamethasone intravitreal implant (Ozurdex®) Non-infections uveitis ICB
Dexamethasone intravitreal implant (Ozurdex®) Diabetic macular oedema ICB
Dexamthasone Intra-erythrocyte Ataxia Telangiectasia NHS England
Dexrazoxane (Savene®1,Cardioxane®2) Anthracycline extravasation (Savene®) NHS England
Dexrazoxane (Savene®1,Cardioxane®2) Anthracycline Cardiotoxicity (Carioxane®) NHS England
Dibotermin alfa  (InductOs®) Complex spinal surgery NHS England
Didanosine  (Videx®) HIV in combination with other anti-retroviral drugs NHS England
Difelikefailin Pruritus associated with chronic kidney disease on haemodialysis NHS England
Digoxin immune fab (DigiFab®) Digoxin toxicity This drug has not been formally commissioned, however due the nature of the indication it is considered that all CCGs would fund.
Dimethyl Fumarate (Skilarence) Moderate to severe plaque psoriasis ICB
Dimethyl Fumarate (Tecfidera®) Multiple sclerosis NHS England
Dirlococtogene Samoparvovec Haemophilia A NHS England
Diroximel fumarate Multiple sclerosis NHS England
Dolutegravir (Tivicay®) HIV in combination with other anti-retroviral drugs NHS England
Doravirine (Pifeltro®) HIV in combination with other anti-retroviral drugs NHS England
Dornase alfa (Pulmozyme®) Cystic Fibrosis NHS England
Dornase alfa (Pulmozyme®) Primary Ciliary Dyskinesia NHS England
Dupilumab (Dupixent®) Moderate to severe atopic dermatitis after topical treatments ICB
Dupilumab (Dupixent®) Asthma NHS England
Durvalumab Cancer NHS England
Duvelisib Cancer TBC
Ecallantide Hereditary angioedema - acute treatment only NHS England
Eculizumab (Soliris®) Atypical Haemolytic Uraemic Syndrom (aHUS) NHS England Central Team
Eculizumab (Soliris®) Neuromyelitis optica NHS England
Eculizumab (Soliris®) Paroxysmal Nocturnal Haemoglobinuria NHS England Central Team
Eculizumab (Soliris®) Organ Rejection post kidney transplant NHS England Central Team
Eculizumab (Soliris®) C3 Glomerulopathy (post-transplant) NHS England Central Team
Eculizumab (Soliris®) Delayed haemolytic transfusion reactions and hyperhaemolysis in patients with haemoglobinopathies NHS England
Efavirenz (Sustiva®) HIV in combination with other anti-retroviral drugs NHS England
Efgartigimod alfa Myasthenia Gravis NHS England
Efmoroctocog alfa (Efraloctocog alfa) (Factor VIII - recombinant) Haemophilia A NHS England
Efraloctocog alfa ( see efmoroctocog alfa) (Factor VIII - recombinant) Haemophilia A NHS England
Efrenonacog alfa (see Eftrenonacog alfa) (Factor IX - recombinant) Haemophilia B NHS England
Eftrenonacog alfa (efrenonacog alfa) (Factor IX - rembinant) Haemophilia B NHS England
Eladocagene Exuparovec (Upstaza®) Aromatic L-amino acid decarboxylase (AADC) Deficiency NHS England
Elbasvir+ Grazoprevir (Zepatier®) Hepatitis C NHS England
Elexacaftor/Tezacaftor/Ivacaftor (Kaftrio®) Cystic Fibrosis NHS England
Eliglustat (Cerdelga®) Gaucher’s Disease NHS England
Elosulfase alfa (Vimizim®) Mucopolysaccharidosis Type 4A  NHS England
Elotuzumab Cancer NHS England
Eltrombopag (Revolade®) Thrombocytopenia purpura ICB
Eltrombopag (Revolade®) Severe aplastic anaemia in adults ICB
Elvitegravir (Vitekta®) HIV in combination with other anti-retroviral drugs NHS England
Elvucitabine HIV in combination with other anti-retroviral drugs NHS England
Emicizumab (Hemlibra®) As per BCSH Guidelines for specialised indications NHS England
Emiplacel Muscle injury following arthroplasty NHS England
Emixustat Stargardt's disease NHS England
Emtricitabine (Emtriva®) HIV in combination with other anti-retroviral drugs NHS England
Enfortumab vedotin Cancer TBC
Enfuvirtide (Fuzeon®) HIV in combination with other anti-retroviral drugs NHS England
Enzalutamide (Xtandi®) Cancer NHS England
Eplontersen Amyloidosis NHS England
Epoetin Alpha, Beta, Theta and Zeta Dialysis - induced anaemia NHS England
Epoprostenol (Flolan®) Digital Ulcers NHS England
Epoprostenol (Flolan®) Pulmonary Arterial Hypertension NHS England
Epratuzumab SLE NHS England
Eprodisate Amyloidosis NHS England
Eptacog alfa (activated) (Factor VIIa - recombinant) as per BCSH guidelines for specialised indications NHS England
Eptacog Beta (activated) (Factor VIIa - recombinant) as per BCSH guidelines for specialised indications NHS England
Eptinezumab (Vyepti®) Migraine ICB
Eptotermin alfa (Opgenra®) Complex spinal surgery NHS England
Erenumab (Aimovig®) Migraine ICB
Erlotinib Cancer NHS England
Etanercept (Enbrel®, Erelzi®, Benepali®) Adult Onset Still's disease ICB
Etanercept (Enbrel®, Erelzi®, Benepali®) Ankylosing spondylitis ICB
Etanercept (Enbrel®, Erelzi®, Benepali®) Psoriasis ICB
Etanercept (Enbrel®, Erelzi®, Benepali®) Psoriatic Arthritis ICB
Etanercept (Enbrel®, Erelzi®, Benepali®) Rheumatoid arthritis ICB
Etanercept (Enbrel®, Erelzi®, Benepali®) Juvenile arthritis (adult) ICB
Etanercept (Enbrel®, Erelzi®, Benepali®) Plaque psoriasis in children NHS England
Etanercept (Enbrel®, Erelzi®, Benepali®) Juvenile arthritis (paediatric) NHS England
Eteplirsen (Exondys®) Duchenne Muscular Dystrophy NHS England
Etranacogene Dezaparovovec Haemophilia B TBC
Etravirine (Intelence®) HIV in combination with other anti-retroviral drugs NHS England
Everolimus (Afinitor®) Cancer NHS England
Everolimus (Certican®) Preventing organ rejection in liver transplantation NHS England
Everolimus (Certican®) Preventing organ rejection in heart transplantation NHS England
Everolimus (Votubia®) Renal angiomyolipoma associated with Tubular sclerosis NHS England
Everolimus (Votubia®) Seizures associated with subependymal giant cell astrocytoma (sega) associated with tubular sclerosis  NHS England
Everolimus (Votubia®) Kidney transplant - adults/children & young people NHS England
Everolimus (Votubia®) Subependymal giant cell astrocytoma (SEGA) associated with Tubular sclerosis NHS England
Evinacumab Homozygous familial hypercholesterolemia NHS England
Evolocumab (Repatha SureClick®) Primary hypercholesterolaemia or mixed dyslipidaemia ICB
Evolocumab (Repatha SureClick®) Primary heterozygous-familial hypercholesterolaemia ICB
Evolocumab (Repatha SureClick®) Homozygous familial hypercholesterolemia NHS England
Exagamglogene autotemcel Thalassaemia and sickle cell disease NHS England
Ex-vivo expanded autologous human corneal epithelial cells containing stem cells 1 (Holoclar®) Treatment of adult patients with moderate to severe limbal stem-cell deficiency (LSCD), unilateral or bilateral, due to physical or chemical ocular burns. NHS England
Factor IX As per BCSH Guidelines NHS England
Factor VII As per BCSH Guidelines NHS England
Factor VIIa As per BCSH Guidelines NHS England
Factor VIII As per BCSH Guidelines NHS England
Factor VIII + von willebrand factor  Von willebrand deficiency NHS England
Factor VIII Inhibitor Bypassing Factor (FEIBA) As per BCSH Guidelines NHS England
Factor XIII As per BCSH Guidelines NHS England
Factor XI As per BCSH Guidelines NHS England
Fampridine (Fampyra®) Multiple Sclerosis NHS England
Faricimab (Vabysmo®) Diabetic Macular Oedema ICB
Faricimab (Vabysmo®) Macular degeneration(wet age-related) ICB
Fedratinib (Inrebic®) Myelofibrosis CDF
Fenfluramine (Fintepla®) Dravet Syndrome NHS England
Fibrinogen As per BCSH Guidelines for specialised indications NHS England
Fidanacogene elaparvovec Haemophilia B  
Fidaxomicin Recurrent Clostridium Difficile Infection ICB
Filgotinib (Jyseleca®) Ulcerative Colitis (moderate to severe) ICB
Filgotinib (Jyseleca®) Moderate to Severe Rheumatoid Arthritis ICB
Fingolumod  (Gilenya®) Multiple Sclerosis NHS England
Fitusiran Haemophilia A and B  
Fluocinolone acetonide (Iluvien®) Non-infections uveitis ICB
Fluocinolone acetonide (Iluvien®) Diabetic Macular Oedema ICB
Fomepizole Ethylene glycol poisoning and Methanol poisoning ICB
Fordadistrogene Movaparvovec Duchenne Muscular Dystrophy NHS England
Forigerimod acetate (Lupuzor®) SLE NHS England
Fosamprenavir (Telzir®) HIV in combination with other anti-retroviral drugs NHS England
Fostamatinib (Tavlesse®) Chronic immune thrombocytopenia ICB
Fostemsavir HIV in combination with other anti-retroviral drugs NHS England
Fremanezumab (Ajovy®) Migraine ICB
Galcanezumab (Emgality®) Migraine ICB
Galsulfase (Naglazyme®) Mucopolysaccharidosis NHS England
Ganaxolone Seizures associated with cyclin-dependant kinase-like 5 deficiency disorder NHS England
Gefitinib (Iressa®)  Cancer NHS England
Giroctocogene fitelparvovec Haemophilia A  
Givosiran (Givlaari®) Hepatic porphyria NHS England
Glatiramer acetate (Copaxone®) Multiple Sclerosis NHS England
Glecaprevir + Pibrentasvir Hepatitis C NHS England
Glucarpidase Methotrexate induced renal dysfunction NHS England
Glycerol Phenylbutyrate (Ravicti®) Urea Cycle Disorders NHS England
Golimumab (Simponi®) Ankylosing Spondylitis ICB
Golimumab (Simponi®) Psoriatic arthritis ICB
Golimumab (Simponi®) Rheumatoid arthritis ICB
Golimumab (Simponi®) Ulcerative Colitis (moderate to severe) ICB
Granulocyte-macrophage colony-stimulating factor (Leukine® - Import) Antibody-positive pulmonary alveolar proteinosis NHS England
Guselkumab (Tremfya ®) Psoriatic arthritis ICB
Guselkumab (Tremfya ®) Moderate to severe plaque psoriasis ICB
Haem Arginate Hepatic Porphyria NHS England
Human alpha - 1 proteinase inhibitor  Emphysema NHS England
Human coagulation factor X Factor X deficiency NHS England
Human (haem) Arginate (Normosang®) Hepatic porphyria NHS England
Human heterologous liver cells Urea Cycle Disorders NHS England
Human parathyroid hormone-related protein analogue (Abaloparatide analogue) Male juvenile osteoporosis NHS England
Hydroxypropyl Betadex   NHS England
Ibalizumab (Trogarzo®) HIV in combination with other anti-retroviral drugs NHS England
Icatibant (Firazyr®) Hereditary angioedema - acute treatment only NHS England
Idebenone (Raxone ®) Duchenne muscular dystrophy NHS England
Idebenone (Raxone ®) Lebers hereditary optic neuropathy NHS England
Idecabtagene Vicleucel Cancer NHS England
Idursulfase (Elaprase®) Mucopolysaccharidosis NHS England
Iloprost (Ventavis®) Digital Ulcers NHS England
Iloprost (Ventavis®) Pulmonary Arterial Hypertension NHS England
Imatinib (Glivec®) Cancer NHS England
Imatinib (Glivec®) Graft versus host disease NHS England
Imetelstat Cancer NHS England
Imiglucerase (Cerezyme®) Gaucher’s Disease NHS England
Imlifidase (Idefirix ®) Transplant rejection prevention in HLA-sensitised patients NHS England
Inclisiran (Leqvio®) Primary hypercholesterolaemia or mixed dyslipidaemia NHS England
Indinavir (Crixivan®) HIV in combination with other anti-retroviral drugs NHS England
Inebilizumab Multiple Sclerosis NHS England
Infliximab (Inflectra, Remsima, Remicade®) Adult Onset Still's disease ICB
Infliximab (Inflectra, Remsima, Remicade®) Ankylosing spondylitis ICB
Infliximab (Inflectra, Remsima, Remicade®) Crohn’s disease ICB
Infliximab (Inflectra, Remsima, Remicade®) Psoriasis ICB
Infliximab (Inflectra, Remsima, Remicade®) Psoriatic Arthritis ICB
Infliximab (Inflectra, Remsima, Remicade®) Rheumatoid arthritis ICB
Infliximab (Inflectra, Remsima, Remicade®) Diarrhoea and colitis relating to ICPI therapy ICB
Infliximab (Inflectra, Remsima, Remicade®) Ulcerative Colitis (moderate to severe) ICB
Infliximab (Inflectra, Remsima, Remicade®) Behcet's Syndrome NHS England
Infliximab (Inflectra, Remsima, Remicade®) Connective tissue disease - interstitial lung disease NHS England
Infliximab (Inflectra, Remsima, Remicade®) Crohn's disease in children NHS England
Infliximab (Inflectra, Remsima, Remicade®) Graft versus host disease NHS England
Infliximab (Inflectra, Remsima, Remicade®) Hidradenitis Suppurativa NHS England
Infliximab (Inflectra, Remsima, Remicade®) Juvenile arthritis NHS England
Infliximab (Inflectra, Remsima, Remicade®) Renal NHS England
Infliximab (Inflectra, Remsima, Remicade®) Pulmonary Sarcoidosis NHS England
Infliximab (Inflectra, Remsima, Remicade®) Sarcoidosis NHS England
Infliximab (Inflectra, Remsima, Remicade®) Uveitis  NHS England
Infliximab (Inflectra, Remsima, Remicade®) Refractory or progressive neurosarcoidosis NHS England
Inotersen (Tegsedi®) Amyloidosis NHS England
Interferon Alfa (IntronA®, Roferon-A®) Hepatitis B and C NHS England
Interferon Alfa N3 Middle East Respiratory Syndrome NHS England
Interferon Beta (Avonex®, Rebif®, (beta-1a) Betaferon®, Extavia® (beta-1b) Multiple Sclerosis NHS England
Intravenous normal human immunoglobulins Multiple indications NHS England
Invertase   NHS England
Invimestrocel (Multistem®) Stroke TBC
Iptacopan Paroxysmal Nocturnal Haemoglobinuria NHS England
Isavuconazole (Cresemba®) Fungal infection (licensed indications) NHS England
Ivacaftor (Kalydeco®) Cystic Fibrosis NHS England
Ixekizumab (Taltz®) Moderate to severe plaque psoriasis ICB
Ixekizumab (Taltz®) Axial spondyloarthritis ICB
Ixekizumab (Taltz®) Psoriatic Arthritis ICB
Ixazomib (Ninlaro®) Amyloidosis NHS England
Ixazomib (Ninlaro®) Multiple Myeloma NHS England
Lanadelumab (Takhzyro®) Hereditary Angioedema NHS England
Lanreotide (Somatuline® LA, Somatuline Autogel®) Cancer NHS England
Lanreotide (Somatuline® LA, Somatuline Autogel®) Acromegaly NHS England
Lanreotide (Somatuline® LA, Somatuline Autogel®) Congenital hyperinsulinism NHS England
Lapatinib (Tyverb®) Cancer NHS England
Laronidase (Aldurazyme®) Mucopolysaccharidosis NHS England
L-Arginine Urea Cycle Disorders NHS England
Lebrikizumab Asthma NHS England
Ledipasvir/Sofosbuvir +/- Ribavirin Hepatitis C NHS England
Lenacapavir HIV NHS England
Lenadogene Nolparvovec Leber hereditary optic neuropathy NHS England
Lenalidomide (Revlimid®) Cancer NHS England
Lenalidomide (Revlimid®) POEMS NHS England
Leniolisib Phospoinositide 3-kinase delta syndrome NHS England
Leriglitazone Adrenleukodystrophy NHS England
Leronlimab HIV in combination with other anti-retroviral drugs NHS England
Letermovir (Prevymis®) Cytomegalovirus NHS England
Levodopa + Carbidopa + entacapone (Intestinal gel) Parkinson’s disease NHS England
Levofloxacin (inhaled) (Aeroquin® / Quinsair®) Cystic Fibrosis NHS England
Levoketoconazole (Normo-Cort®) Cushing's Disease NHS England
Lifileucel Cancer TBC
Liothyronine Myxoedema coma ICB
Lisocabtagene Maraleucel (Breyanzi®) Cancer TBC
Lomitapide (Lojuxta®) Homozygous familial hypercholesterolemia NHS England
Lonafarinib Cancer NHS England
Lonoctocog alfa (Factor VIII- recombinant) Haeophilia A NHS England
Lopinavir HIV in combination with other anti-retroviral drugs NHS England
Lorlatinib (Lorviqua®) Cancer NHS England
Lumacaftor with Ivacaftor (Orkambi®) Cystic Fibrosis NHS England
Lumasiran Primary Hyperoxsluria NHS England
Lusutrombopag (Mulpleo ®) Thrombocytopenia in people with chronic liver disease ICB
Luspatercept Cancer NHS England
Macitentan (Opsumit®) Pulmonary Arterial Hypertension NHS England
Mannitol (Bronchitol®) Cystic Fibrosis NHS England
Maralixibat Alagille syndrome NHS England
Maraviroc (Celsentri®) Natalizumab induced PML NHS England
Maraviroc (Celsentri®) HIV in combination with other anti-retroviral drugs NHS England
Maribavir Cytomegalovirus NHS England
Marnetegragene autoemcel Leukocyte adhesion deficiency - 1 (LAD-1) NHS England
Masitinib (Masican®, Masiviera®) Pancreatic cancer/GIST NHS England
Mavacamten Symptomatic hypertrophic cardiomyopathy NHS England
Mecasermin (Increlex®) Growth Failure NHS England
Mepolizumab (Nucala®) Asthma NHS England
Mercaptamine HCL viscous eyedrops Corneal cystine deposits NHS England
Metreleptin (Myalepta®) Congenital leptin deficiency NHS England
Metreleptin (Myalepta®) Dyslipidaemia NHS England
Metreleptin (Myalepta®) Lypodystrophy NHS England
Mexiletine (Namuscla®) Non dystrophic myotonia NHS England
Micafungin (Mycamine®) Fungal infection NHS England
Migalastat (Galafold®) Fabry’s Disease NHS England
Miglustat (Zavesca®) Gaucher's disease/Niemann- Pick NHS England
Mitapivat Protein kinase deficiency NHS England
Mobocertinib Cancer NHS England
Mogamulizumab (Poteligeo®) Mycosis Fungoides NHS England
Momelotinib Cancer NHS England
Moroctocog alfa (Factor VIII- recombinant) Haemphilia A NHS England
Mosunetuzumab Cancer TBC
Mozafancogene autotemcel Fanconi anaemia NHS England
Mycophenolic acid (sodium salt) Transplant immunosuppression only Kidney transplant - adults/ children & young people NHS England
Nadofarangene firadenovec Cancer - bladder NHS England
Narsoplimab Haematopoietic stem cell transplanted-related thrombotic microangiopathy (HSCT-TMS) NHS England
Natalizumab (Tysabri®) Multiple Sclerosis NHS England
Navitoclax Myelofibrosis NHS England
Nedosiran Hyperoxaluria NHS England
Nelfinavir (Viracept®) HIV in combination with other anti-retroviral drugs NHS England
Nevirapine (Viramune®) HIV in combination with other anti-retroviral drugs NHS England
Nexobrid (Bromelain)   NHS England
Nicardipine - intracranial implant Subarachnoid Haemorrhage NHS England
Nilotinib (Tasigna®) Cancer NHS England
Nintedanib (Ofev®) Idiopathic pulmonary fibrosis NHS England
Nintendanib Progressive fibrosing interstitial lung diseases NHS England
Nintedanib (Vargatef®)  Cancer NHS England
Nirsevimab RSV prophylaxis NHS England
Nitazoxanide (Alinia®) Hepatitis C NHS England
Nitisinone (Orfadin®) Alkaptonuria NHS England
Nitisinone (Orfadin®) Tyrosinaemia NHS England
Nitric Oxide Pulmonary Arterial Hypertension NHS England
Nonacog alfa (Factor IX - rembinant) Haemophilia B NHS England
Nonacog Beta pegol (Factor IX - recombinant) Haemophilia B NHS England
Nonacog gamma (Factor IX - recombinant) Haemophilia B NHS England
Nusinersen (Spinraza®) Spinal muscular atrophy NHS England
Obecabtagene autoleucel Cancer NHS England
Obeticholic Acid (Ocaliva®) Primary biliary cirrhosis NHS England
Obiltoxaximab Anthrax NHS England
Ocrelizumab (Ocrevus®) Primary progressive multiple sclerosis NHS England
Ocrelizumab (Ocrevus®) Multiple Sclerosis NHS England
Ocriplasmin (Jetrea®) Retinal disorders- Vitreomacular traction ICB
Octocog alfa (Factor VIII - recombinant) Haemophilia A  
Octreolin (Mycapssa®) Acromegaly NHS England
Octreotide (Sandostatin®, SandostatinLar®) Cancer NHS England
Octreotide (Sandostatin®, SandostatinLar®) Acromegaly NHS England
Octreotide (Sandostatin®, SandostatinLar®) Congenital hyperinsulinism NHS England
Odevixibat Progressive familial Intrahepatic cholestasis NHS England
Ofatumumab (Kesimpta®) Multiple Sclerosis NHS England
Olenasulfligene relduparvovec Mucopolysaccharidosis NHS England
Olipudase alfa Acid sphingomyelinase deficiency NHS England
Omalizumab (Xolair®) Severe Chronic Spontaneous Urticaria ICB
Omalizumab (Xolair®) Asthma NHS England
Ombitasvir/Paritaprevir/ Ritonavir with Dasabuvir +/- Ribavirin (Viekirax®) Hepatitis C NHS England
Onasemnogene abeparvovec (Zolgensma®) Spinal Muscular atrophy NHS England
Osteochondral allograft Osteochondral lesions knee NHS England
Ozanimod (Zeposia®) Moderately to severe ulceratve colitis ICB
Ozanimod Multiple Sclerosis NHS England
Pacritinib (Epjevy®) Myelofibrosis NHS England
Palivizumab (Synagis®) Respiratory Syncytial Virus Prophylaxis NHS England
Palopegteriparatide Hypoparathyroidism NHS England
Palovarotene Fybrodysplasia ossificans progressiva NHS England
Para- aminosalicylic acid (GranuPAS®) Tuberculosis NHS England
Parathyroid Hormone (Preotact®) Osteoporosis ICB
Parathyroid Hormone (Preotact®) Specialist endocrinology conditions NHS England
Parenteral Nutrition (Home use) Intestinal Failure NHS England
Parenteral Nutrition (Inpatient use) Intestinal Failure; inadequate/unsafe enteral feeding NHS England
Paricalcitol (Zemplar®) Hyperparathyroidism NHS England
Paritaprevir Hepatitis C NHS England
Pasireotide (Signifor®) Acromegaly NHS England
Pasireotide diaspartate Cushing's Disease NHS England
Patisiran (Onpattro) Amyloidosis NHS England
Pazopanib (Votrient®) Cancer NHS England
Pegbelfermin Alcoholic fatty Liver disease NHS England
Pegcetacoplan (Empaveli®) Paroxysmal Nocturnal Haemoglobinuria NHS England
Peginterferon alfa (Pegasys®, ViraferonPeg®) Hepatitis B and C NHS England
Peginterferon beta-1A (Plegridy®) Multiple Sclerosis NHS England
Pegunigalsidase alfa Fabry’s Disease NHS England
Pegvaliase (Palynziq®) Phenylketonuria NHS England
Pegvisomant  (Somavert®) Acromegaly NHS England
Pembrolizumab (Keytruda®) Drug resistant gestational trophoblastic neoplasia NHS England
Pemigatinib (Pemazyre®) Cancer NHS England
Pibrentasvir Hepatitis C NHS England
Pirfenidone (Esbriet®) Idiopathic pulmonary fibrosis NHS England
Platelet lysate therapy   NHS England
Plerixafor (Mozobil®) Stem cell mobilisation NHS England
Pomalidomide (Imnnovid®) Cancer NHS England
Pomalidomide (Imnnovid®) Myelofibrosis NHS England
Ponatinib (Iclusig®) Cancer NHS England
Ponesimod (Ponvory®) Multiple Sclerosis NHS England
Posaconazole (Noxafil®) Fungal Infection NHS England
Pralsetinib Cancer TBC
Pretomanid Multi drug resistant TB NHS England
Protein C As per BCSH Guidelines for specialised indications NHS England
Prothrombin complex As per BCSH Guidelines for specialised indications NHS England
Raltegravir  (Isentress®) HIV in combination with other anti-retroviral drugs NHS England
Ranibizumab (Lucentis®/ Ongavia®) Retinopathy of prematurity NHS England
Ranibizumab (Lucentis®/ Ongavia®) Macular oedema (Retinal vein occlusion) ICB
Ranibizumab (Lucentis®/ Ongavia®) Diabetic Macular Oedema ICB
Ranibizumab (Lucentis®/ Ongavia®) Macular degeneration(wet age-related) ICB
Ranibizumab (Lucentis®/ Ongavia®) Choroidal neovascularisation (CNV) associated with pathological myopia ICB
Rasburicase (Fasturtec®) Hyperuricaemia NHS England
Ravulizumab  Paroxysmal Nocturnal Haemoglobinuria NHS England
Ravulizumab  AHUS NHS England
Regorafenib (Stivarga®) Cancer NHS England
Reparixin Prevention of delayed graft function NHS England
Reslizumab (Cinquil®) Asthma NHS England
Rezafungin Candidiasis NHS England
Rilpivirine (Edurant®) HIV in combination with other anti-retroviral drugs NHS England
Rimegepant (Vydura®) Migraine ICB
Riociguat (Adempas®) Pulmonary Arterial Hypertension (CTEPH) NHS England
Riociguat (Adempas®) Pulmonary Arterial Hypertension NHS England
Ripretinib Cancer NHS England
Risankizumab (Skyrizi®) Crohn's disease (Adolescents 16-17yrs) NHS England
Risankizumab (Skyrizi®) Psoriatic Arthritis ICB
Risankizumab (Skyrizi®) Crohn's disease ICB
Risankizumab (Skyrizi®) Moderate to severe plaque psoriasis ICB
Risdiplam (Evrysdi®) Spinal muscular atrophy NHS England
Ritonavir  (Norvir®) HIV in combination with other anti-retroviral drugs NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Rheumatoid Arthritis ICB
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Immune (idiopathic) thrombocytopenic purpura (ITP) ICB
Rituximab (Mabthera®, Truxima ®, Rixathon ®) ABO-incompatible kidney transplants NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Acquired Haemophilia NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) ANCA-associated vasculitis NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Anti-Inmdar autoimmune encephalitis NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Chronic inflammatory demyelinating polyneuropathy NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Connective tissue disease - interstitial lung disease NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Dermatomyositis and Polymyositis (Adults) NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Graft versus host disease NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) IGM Paraproteinaemic demyelinating peripheral neuropathy NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Juvenile Arthritis (paediatric) NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Membranous Nepropathy NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Multifocal motor neuropathy NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Myasthenia Gravis NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Myositis NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Nephritis NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Neuromyelitis optica NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Nodal/paranodal antibody positive inflammator/autoimmune neuropathy NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Pemphigus vulgaris NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Primary Sjogren's Syndrome (PSS) NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Systemic lupus erythematosus (SLE) NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Steroid resistant nepprotic syndrome - paediatrics NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Steroid sensitive nephrotic syndrome NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Vasculitis of peripheral nervous system NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Immunoglobulin G4 Related Disease NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Focal segmental glomerulosclerosis NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Delayed haemolytic transfusion reactions and hyperhaemolysis in patients with haemoglobinopathies NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Immunobullous disease NHS England
Rituximab (Mabthera®, Truxima ®, Rixathon ®) Castleman's disease NHS England
Rituximab IV Cancer NHS England
Rituximab S/C Cancer NHS England
Rivipansel sodium Hepatic veno-occlusive disease NHS England
Rivipansel sodium Sickle Cell Disease NHS England
Romiplostim (Nplate®) Thrombocytopenia purpura ICB
Romosozumab (Evenity®) Osteoporosis ICB
Ropeginterferon alfa-2b Hepatitis C NHS England
Roxadustat Symptomatic anaemia in chronic kidney disease ICB
RP-L102 Fanconi anaemia  
RP-L201 Leukocyte adhesion deficiency - 1 (LAD-1) NHS England
Rurioctocog alfa pegol Haemophilia A NHS England
Ruxolitinib  (Jakavi®)  Cancer NHS England
Sacituzumab govitecan Cancer NHS England
Sapropterin (Kuvan®) Adults and Children with tetrahydrobiopterin disorders NHS England
Sapropterin (Kuvan®) Adults and Children with Phenylketonuria NHS England
Saquinavir (Invirase®) HIV in combination with other anti-retroviral drugs NHS England
Sarilumab (Kevzara®) Rheumatoid Arthritis ICB
Satralizumab Neuromyelitis optica NHS England
Sebelipase alfa (Kanuma®) Lysosomal acid lipase deficiency NHS England
Secukinumab (Cosentyx®) Plaque psoriasis in children NHS England
Secukinumab (Cosentyx®) Ankylosing spondylitis ICB
Secukinumab (Cosentyx®) Moderate to severe plaque psoriasis ICB
Secukinumab (Cosentyx®) Non-radiographic axial spondyloarthritis ICB
Secukinumab (Cosentyx®) Psoriatic Arthritis ICB
Selexipag (Uptravi®) Pulmonary hypertension NHS England
Selpercatinib Cancer CDF
Selumetinib Neurofibromatosis NHS England
Setmelanotide Leptin deficiency NHS England
Setrusumab Osteogenesis imperfecta NHS England
Sildenafil Pulmonary arterial hypertension NHS England
Siltuximab Castleman's disease NHS England
Simoctocog alfa (Factor VIII - recombinant) Haemophilia A NHS England
Siponimod (Mayzent®) Multiple Sclerosis NHS England
Sirolimus (Rapamune®) Transplant immunosuppression only  kidney transplant - adults/ children & young people NHS England
Sitoiganap (Gliovac®) Cancer NHS England
Sodium Benzoate Urea cycle disorders NHS England
Sodium Hydroxybutyrate Urea cycle disorders NHS England
Sodium Oxybate (Xyrem®) Narcolepsy - paediatric services only NHS England
Sodium Phenylbutyrate (Ammonaps®) Urea cycle disorders NHS England
Sodium thiosulfate Prevention of hearing loss NHS England
Sofosbuvir/Ledipasvir+/- Ribavirin (Harvoni®) Hepatitis C NHS England
Sofosbuvir/Peginterferon + Ribavirin Hepatitis C NHS England
Sofosbuvir/Velpatasvir (Epclusa®) Hepatitis C NHS England
Sofosbuvir + velpatasvir +voxilaprevir Hepatitis C NHS England
Somatrogon (Ngenla®) Growth Failure ICB
Sorafenib (Nexavar®) Cancer NHS England
Sotorasib (Lumykras®) Cancer CDF
Spheroids of human autologous matrix-associated ahondrocytes Cartilage disorders NHS England
Stavudine (Zerit®) HIV in combination with other anti-retroviral drugs NHS England
Subcutaneous Human normal immunoglobulins Multiple indications NHS England
Sucroferric oxyhydroxide (Velphoro®) Adult Renal dialysis only  NHS England
Sunitinib (Sutent®) Cancer NHS England
Susoctocog alfa (Factor VIII - porcine recombinant) Acquired Haemophilia A NHS England
Sutimlimab Primary cold agglutinin disease NHS England
Tabelecleucel Cancer NHS England
Tacrolimus Transplant immunosuppression only NHS England
Tadalafil Pulmonary arterial hypertension NHS England
Tafamandis Amyloidosis NHS England
Tafasitamab Cancer NHS England
Tagraxofusp Cancer TBC
Talazoparib Cancer TBC
Tebentafusp Cancer TBC
Teclistamab Cancer NHS England
Teduglutide (Revestive®) Short Bowel syndrome NHS England
Telbivudine (Sebivo®) Hepatitis B NHS England
Temsirolimus Cancer NHS England
Tenofovir (Viread®) HIV in combination with other anti-retroviral drugs NHS England
Tenofovir (Viread®) Hepatitis B +/- other anti-retroviral drugs NHS England
Tenofovir Alafenamide (Vemlidy®) Hepatitis B NHS England
Tenofovir Alafenamide (Vemlidy®) HIV in combination with other anti-retroviral drugs NHS England
Tenofovir Disproxil HIV in combination with other anti-retroviral drugs NHS England
Teprasiren Prevention of delayed graft function NHS England
Teprotumumab Graves orbitopathy NHS England
Teriflunomide (Aubagio®) Multiple Sclerosis NHS England
Tezacaftor with ivacaftor Cystic Fibrosis NHS England
Tezepelumab Asthma NHS England
Thalidomide (Thalidomide Celegene®) Cancer NHS England
Thrombomodulin, recombinant human Pseudoaneurysm NHS England
Tideglusib Congenital Myotonic Dystrophy NHS England
Tildrakizumab (Ilumetri®) Moderate to severe plaque psoriasis ICB
Tipranavir (Aptivus®) HIV in combination with other anti-retroviral drugs NHS England
Tobramycin (for nebulisation) (Tobi®, Bramitob®) Cystic Fibrosis NHS England
Tocilizumab (RoActemra®) Rheumatoid Arthritis ICB
Tocilizumab (RoActemra®) Juvenile arthritis (adult) ICB
Tocilizumab (RoActemra®) Juvenile arthritis (paediatric) NHS England
Tocilizumab (RoActemra®) Adult Onset Still's disease NHS England
Tocilizumab (RoActemra®) Takayasu arteritis NHS England
Tocilizumab (RoActemra®) Giant cell arteritis NHS England
Tocilizumab (RoActemra®) Castleman's disease NHS England
Tocilizumab (RoActemra®) Cytokine release syndrome NHS England
Tofacitinib (Xeljanz®) Juvenile ioiopathic arthritis - paediatrics NHS England
Tofacitinib (Xeljanz®) Rheumatoid Arthritis ICB
Tofacitinib (Xeljanz®) Psoriatic Arthritis ICB
Tofacitinib (Xeljanz®) Moderately to severe ulceratve colitis ICB
Tofacitinib (Xeljanz®) Juvenile Idiopathic arthritis (adult only)  ICB
Tofersen sodium Amyotrophic lateral sclerosis (Motor neurone disease) NHS England
Tolvaptan (Samsca®) Autosomal dominant polycystic kidney disease ICB
Tolvaptan (Samsca®) Hyponatraemia in cancer NHS England
Tralokinumab (Adtralza®) Moderate to severe atopic dermatitis ICB
Tralokinumab Asthma NHS England
Trenonacog alpha Haemophilia B NHS England
Treosulfan (Trecondi®) Cancer NHS England
Treprostinil Diethanolamine Pulmonary arterial hypertension NHS England
Treprostinil Sodium  (Tyvaso®) Pulmonary arterial hypertension NHS England
Trientine  Wilson's Disease NHS England
Triheptanoin  Pyruvate carboxylase deficiency NHS England
Tucatinib (Tukysa®) Cancer NHS England
Turoctocog alfa (Factor VIII - recombinant) Haemophilia A NHS England
Turoctocog alfa pegol (Factor VIII - recombinant) Haemophilia A NHS England
Upadacitinib (Rinvoq®) Moderate to severe atopic dermatitis - paediatrics NHS England
Upadacitinib (Rinvoq®) Crohn's disease ICB
Upadacitinib (Rinvoq®) Ulcerative Colitis ICB
Upadacitinib (Rinvoq®) Non-radiographic axial spondyloarthritis ICB
Upadacitinib (Rinvoq®) Moderate to severe atopic dermatitis ICB
Upadacitinib (Rinvoq®) Ankylosing spondylitis ICB
Upadacitinib (Rinvoq®) Psoriatic Arthritis ICB
Upadacitinib (Rinvoq®) Rheumatoid Arthritis ICB
Upbituximab Multiple Sclerosis NHS England
Ustekinumab (Stelara®) Psoriasis ICB
Ustekinumab (Stelara®) Psoriatic Arthritis ICB
Ustekinumab (Stelara®) Crohn’s disease ICB
Ustekinumab (Stelara®) Ulcerative Colitis (moderate to severe) ICB
Ustekinumab (Stelara®) Plaque psoriasis in children NHS England
Ustekinumab (Stelara®) Crohn's disease - refractory in pre-pubescent children - paediatrics NHS England
Vadadustat Dialysis - induced anaemia NHS England
Vamorolone Duchenne muscular dystrophy NHS England
Vandetanib (Caprelsa®) Thyroid cancer NHS England
Vatiquinone Friedreichs ataxia NHS England
Vedolizumab (Entyvio®) Ulcerative Colitis (moderate to severe) ICB
Vedolizumab (Entyvio®) Crohn’s disease ICB
Vedolizumab (Entyvio®) Ulcerative colitis  - refractory in pre-pubescent children - paediatrics NHS England
Velaglucerase alfa (VPRIV®) Gaucher’s Disease NHS England
Velmanase alfa (Lamzede®) Alpha Mannosidase Deficiency NHS England
Vemurafenib (Zelboraf®) Melanoma NHS England
Verteporfin (Visudyne®) Central serous chorioretinopathy ICB
Verteporfin (Visudyne®) Polypoidal choroidal vasculopathy ICB
Vestronidase alfa (Mepsevii®) Mucopolysaccharidosis VIII NHS England
Voclosporin Lupus nephritis NHS England
Volanesorsen (Waylivra®) Familial Chylomicronemia syndrome NHS England
Vonicog alfa (Veyvondi®) Von Willebrand Deficiency NHS England
Von willebrand factor (Von willebrand factor - plasma derived)(Willfact®) Von willebrand deficiency NHS England
Voretigene Neparvovec (Luxturna®) Inherited retinal disorders NHS England
Voriconazole (Vfend®) Fungal infection NHS England
Voriconazole (Vfend®) Chronic pulmonary aspergillosis NHS England
Vosoritide Achondroplasia (dwarfism) in children NHS England
Voxelotor Sickle Cell Disease NHS England
Vutisiran Amyloidosis NHS England
Zanubrutinib Cancer NHS England
Zidovudine (Retrovir®) HIV in combination with other anti-retroviral drugs NHS England
Zilucoplan Myasthenia Gravis NHS England
  • First Line Choice
  • On Formulary
  • Specialist Initiation Only
  • Hospital Only
  • KMPT Initiation Only
  •