Medway Community Healthcare Medway NHS Trust Foundation Trust
Medway Clinical Commissioning Group Swale Clinical Commissioning Group

MHRA Drug Safety Updates

Issue/Date Publications
N/A These will now be included with in the Medicines Optimisation monthly Newsletter
Issue 34 - Jul 22
  •  Topiramate and known harms if used in pregnancy
  • New national safety review of topiramate
  • Further details on the findings of the new study
  • Topiramate and current pregnancy prevention requirements
  • Advice on contraceptive interactions
  • Valproate: current strict restrictions
  • Medicines and Pregnancy Registry
  • Report suspected reactions on a Yellow Card
Issue 33 - 28/04/22
  • Amiodarone (Cordarone X): reminder of risks of treatment and need for patient monitoring and supervision
  • Metformin in pregnancy: study shows no safety concerns
  • Cladribine (Mavenclad): new advice to minimise risk of serious liver injury – HOSPITAL ONLY
  • COVID-19 vaccines and medicines: updates for March 2022
  • Letters and medicine recalls sent to healthcare professionals in February 2022
 Issue 32 -24/03/22
  • Hydroxychloroquine, chloroquine: increased risk of cardiovascular events when used with macrolide antibiotics; reminder of psychiatric reactions
  • COVID-19 antivirals: reporting to the UK COVID-19 Antivirals Pregnancy Registry
  • COVID-19 vaccines and medicines: updates for February 2022
  • Letters and medicine recalls sent to healthcare professionals in January 2022
  • First Line Choice
  • On Formulary
  • Specialist Initiation Only
  • Hospital Only
  • KMPT Initiation Only
  •