1.2.2.5 Opioid Receptor Antagonists

FOR PRIMARY CARE USE:

Naloxegol is recommended as an option for treating opioid induced constipation in adults whose constipation has not adequately responded to laxatives. An inadequate response is defined as opioid-induced constipation symptoms of at least moderate severity in at least 1 of the 4 stool symptom domains (that is,incomplete bowel movement, hard stools, straining or false alarms) while taking at least 1 laxative class for at least 4 days during the prior 2 weeks.

For full details see Gastro-intestinal system - guidance page  Naloxegol for treating opioid‑induced constipation NICE TA345  or  NICE TA345

FOR PRIMARY CARE USE:

Naldemedine is recommended as an option for treating opioid induced constipation in adults whose constipation has not adequately responded to laxatives. An inadequate response is defined as opioid-induced constipation symptoms of at least moderate severity in at least 1 of the 4 stool symptom domains (that is, incomplete bowel movement, hard stools, straining or false alarms) while taking at least 1 laxative class for at least 4 days during the prior 2 weeks.

For full details see Gastro-intestinal system - guidance page Naldemedine for treating opioid-induced constipation NICE guidance [TA651] or NICE TA 651